Comment on "Research on values of GDF-15 level in the diagnosis of primary liver cancer and evaluation of chemotherapeutic effect"

Comment on research on values of GDF-15 level in the diagnosis of primary liver cancer and evaluation of chemotherapeutic effec

Use of complementary and alternative medicine (CAM) in cancer patients. An italian multicenter survey

INTRODUCTION: Complementary and Alternative Medicine (CAM) include a wide range of products (herbs, vitamins, minerals, and probiotics) and medical practices, developed outside of the mainstream Western medicine. Patients with cancer are more likely to resort to CAM first or then in their disease history; the potential side effects as well as the costs of such practices are largely underestimated. PATIENTS AND METHOD: We conducted a descriptive survey in five Italian hospitals involving 468 patients with different malignancies. The survey consisted of a forty-two question questionnaire, patients were eligible if they were Italian-speaking and receiving an anticancer treatment at the time of the survey or had received an anticancer treatment no more than three years before participating in the survey. RESULTS: Of our patients, 48.9% said they use or have recently used CAM. The univariate analysis showed that female gender, high education, receiving treatment in a highly specialized institute and receiving chemotherapy are associated with CAM use; at the multivariate analysis high education (Odds Ratio, (OR): 1.96 95% Confidence Interval, CI, 1.27-3.05) and receiving treatment in a specialized cancer center (OR: 2.75 95% CI, 1.53-4.94) were confirmed as risk factors for CAM use. CONCLUSION: Roughly half of our patients receiving treatment for cancer use CAM. It is necessary that health professional explore the use of CAM with their cancer patients, educate them about potentially beneficial therapies in light of the limited available evidence of effectiveness, and work towards an integrated model of health-care provision

Multimodal approach of advanced gastric cancer: Based therapeutic algorithm

Gastric cancer (GC) is the third leading cause of cancer death in both sexes worldwide, with the highest estimated mortality rates in Eastern Asia and the lowest in Northern America. However, the availability of modern treatment has improved the survival and the prognosis is often poor due to biological characteristics of the disease. In oncology, we are living in the "Era" of target treatment and, to know biological aspects, prognostic factors and predictive response informations to therapy in GC is mandatory to apply the best strategy of treatment. The purpose of this review, according to the recently published English literature, is to summarize existing data on prognostic aspects and predictive factors to response to therapy in GC and to analyze also others therapeutic approaches (surgery and radiotherapy) in locally, locally advanced and advanced GC. Moreover, the multidisciplinary approach (chemotherapy, surgery and radiotherapy) can improve the prognosis of GC

Nutrition in oncologic patients during antiblastic treatment.

Cancer may induce weight loss and cachexia, and cancer treatment may contribute to nutritional impairment. Here, we review the literature on the mechanisms of cancer cachexia and the pharmacological interventions both in use in clinical practice and currently under development. Based on this analysis, several nutritional proposals for cancer patients are suggested and the importance of good nutritional status in candidates for hematopoietic stem cell transplantation is highlighted

The role of nutrition in the development of esophageal cancer: What do we know?

Cancer of the esophagus is the eighth most common cancer by incidence worldwide and ranks sixth as the most common cause of cancer death. It is unique among the gastrointestinal tract malignancies because it embodies two distinct histopatologic types, squamous cell carcinoma and adenocarcinoma. Which type of cancer occurs in a given patient or predominates in a given geographic area depends on many variables, including individual lifestyle, socioeconomic pressures, environmental factors and diet and nutrition. Generally for both squamous cell carcinoma and adenocarcinoma of the esophagus case-control studies provide evidence of a protective effect of fruits and vegetables. Here we review the role of nutrition in the etiology of esophageal cancer

Design and test of an innovative static thin target for intense ion beams

In the present work an innovative design for thin target suited for high intensity beam is proposed, which consists in the deposition of the target material on a substrate of pyrolytic graphite, whose in-plane thermal conductivity allows a quick dissipation into a heat sink. Such a target cooling system has been designed for the NUMEN experiment (hosted at LNS-INFN, Catania), which will use targets of particular isotopes under highly intense ion beams. The time evolution and the spatial distribution of the temperature have been numerically calculated. Results of these calculations show that the target/graphite system can tolerate ion beams with intensities of about 50 eμA and energy of 15 MeV/u. A significant nonuniformity in the target thickness would limit the energy resolution of the reaction products. A technique, based on the α-particle transmission, is used for measuring the thickness and uniformity of the target. Preliminary results from tests with this technique applied to the graphite substrate are shown

Fusion and direct reactions for the system 6He + 64Zn at and below the Coulomb barrier

Fusion and transfer + breakup channels have been studied in the collision induced by the two-neutron-halo 6He on a 64Zn target at energies from below to above the Coulomb barrier. For comparison, the reaction induced by the stable isotope 4He on the same target has been studied. The fusion cross section has been measured by using an activation technique, detecting off-line the delayed x-ray activity following the electron capture decay of the evaporation residues. New measurements of the 4He + 64Zn fusion cross section at sub-barrier energies have been performed in order to cover the same energy range of the 6He + 64Zn fusion cross section and to compare the excitation functions for the two systems down to the lowest energy data point measured for 6He. From the new comparison a sub-barrier fusion enhancement has been observed in the 6He case with respect to the 4He one whereas no effect on the 6He fusion cross section has been seen at energies above the barrier. It has been concluded that such enhancement seems to be due to the diffuse halo structure properties of the 6He nucleus. Moreover, the reactions induced by 6He have shown a strong yield of α particles coming from direct processes

Indirect Study of the 16O+16O Fusion Reaction Toward Stellar Energies by the Trojan Horse Method

The 16 O+ 16 O fusion reaction is important in terms of the explosive oxygen burning process during late evolution stage of massive stars as well as understanding of the mechanism of low-energy heavy-ion fusion reactions. We aim to determine the excitation function for the most major exit channels, α + 28 Si and p + 31 P, toward stellar energies indirectly by the Trojan Horse Method via the 16 O( 20 Ne , α 28 Si) α and 16 O( 20 Ne , p 31 P) α three-body reactions. We report preliminary results involving reaction identification, and determination of the momentum distribution of α - 16 O intercluster motion in the projectile 20 Ne nucleus